PRODIGY (PROtein binDIng enerGY prediction) is a web server that predicts binding affinities for protein-protein (PRODIGY) and protein-small ligand (PRODIGY-LIG) complexes as well as if a given interface is biological or crystallographic (PRODIGY-CRYSTAL). To use PRODIGY you just need to provide the three-dimensional structure of your complex/complexes in PDB/mmCIF format or the ID of its PDB entry. Depending on the input data to be used, your request is expected to take a few seconds before you receive the results. If an e-mail address is provided, you will be notified when your job has finished.
PRODIGY-Webinar: learn more about PRODIGY in the 7th BioExcel webinar.
An archive of multiple PDB/mmCIF files (.tar, .tgz, .zip, .bz2 or .tar.gz) can also be provided, together with the interacting chains.
Information about the predictive approach can be found at the online method page.
Once you click on the button, your job will be processed. If you have provided an email address, the link to the output page will be emailed to you.
If no electrostatic energy is provided, the server will run the "No electrostatics prediction" protocol.
Further information is provided in the manual page.